Through the first 10 games of the 2015 season, Lewis had 20 pass breakups, setting a new Michigan record. He ranked second among all players in the NCAA Division I FBS with 21 passes defended. Lewis set a single-season school record with 21 pass breakups in 2015, surpassing the previous record of 18 held by Marlin Jackson (2002) and Leon Hall (2006). Following the 2015 season, Lewis was named to the All-Big Ten defensive first-team, by both the media and coaches. He was also named a First-Team All-Americanby USA Today, and Sports Illustrated, becoming the first Wolverine to earn the honor since Taylor Lewan in 2013, and the first Wolverine defensive back to earn the honor since Leon Hall in 2006.